Work at Charnwood, Leicestershire.

• As a dedicated Research & Development site, our Charnwood site encompasses all major R&D functions, along with essential support services and infrastructure, necessary to achieve its goal to discover and develop new medicines.

• • Charnwood

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Research

Our research work at the Charnwood site is focused on finding new medicines for respiratory diseases such as asthma, chronic bronchitis and emphysema (diseases often associated with smoking and for which new medicines are desperately needed) as well as inflammatory diseases such as rheumatoid and osteoarthritis. A focussed safety assessment unit plays a key role in the research phase.

Development

Our development capabilities at the site include Pharmaceutical and Analytical R&D, Process R&D and Clinical, predominantly for the Respiratory, Inflammation and Cardiovascular areas. Process R&D ensures that commercially viable processes for medicine production are designed, developed and scaled-up for transfer to manufacturing sites. Pharmaceutical and Analytical R&D develops medicine formulations and appropriate delivery devices. The Clinical function designs and delivers clinical trials and programmes around the world to establish the efficacy of new medicines, as well as providing medical and scientific input to the research phase. The Charnwood Clinical facilities include a hospital-based CPU (Clinical Pharmacology Unit) at Nottingham.

The Regulatory function at Charnwood provides in-depth knowledge, interpretation and practical application of regulations governing development, manufacturing, registration, marketing and maintenance of medicines across several disease areas.

Global Expertise

Charnwood's Pharmaceutical and Analytical R&D is AstraZeneca's global centre of excellence for the development of pMDIs (pressurised metered dose inhalers). The Charnwood Clinical function is the company's global clinical centre of excellence for Inflammation. The global Advanced Science & Technology Laboratory, which investigates and evaluates leading edge technology, is also based at Charnwood.